The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector molecule on the cellular response to double-stranded RNA, but it also integrates signals in response to Toll-like receptor activation, growth factors, and diverse cellular stresses.
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Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity. Donahue, and A. Inferences, questions, and possibilities in Toll-like receptor signalling. Ray, and R.
Among the molecules with important biological functions induced by IFN is the double-stranded RNA dsRNA -dependent protein kinase PKR , an enzyme with multiple effects in cells, which plays a critical role in the antiviral defense mechanism of the host 42 , , , , Bell, and A.